Moderna’s Dr. Stephen Hoge on AI and the future of healthcare

Messenger RNA is nature’s software, the instructions that tell every cell in your body what to do. Moderna has spent more than a decade learning to write it.

On Inside Blackstone, Moderna (NASDAQ: MRNA) President Dr. Stephen Hoge sits down with host Christine Anderson to talk about the future of medicine. He explains how mRNA works, where AI in healthcare is accelerating drug discovery, and the science behind why no two cancers are the same. He walks through the engineering behind an individualized cancer treatment made for one patient at a time, and offers his view on what investors may be underestimating about AI in life sciences. Plus, he shares the fasting habit he’s kept for almost 10 years.

The headlines tell you what happened. Inside Blackstone helps you see what may be coming next.

Time stamps (full transcript available here)

• 00:00 — Welcome to Inside Blackstone
• 01:04 — The Monday Morning Meeting
• 03:58 — Economic Weather Report
• 06:27— Dr. Stephen Hoge Comes Inside Blackstone
• 07:11 — What is mRNA?
• 09:03 — How Moderna Designed Its COVID Vaccine in an Hour
• 11:21 — The Case for Optimism on AI in Healthcare
• 15:24 — Inside Moderna’s Melanoma Cancer Vaccine Trial
• 16:30 — Every Cancer is Unique
• 17:56 — Creating Individualized Medications at Scale
• 18:41 — A Medicine for One Patient in Six Weeks
• 22:11 — What Investors May Be Underestimating
• 23:34 — Blackstone Life Sciences and the Moderna Flu Vaccine
• 26:33 — What’s Next: Rare Genetic Disease
• 28:11 — STEM + Humanities
• 28:57 — Fasting Two Days a Week
• 30:12 — The Debrief

Key takeaways

• mRNA works like software. Once Moderna cracked the code for one medicine, it could copy and paste to treat multiple diseases.
• AI is speeding up discovery, but medicine is still physical. A treatment still has to be made, tested in people, and given time to show results.
• Personalized medicine requires a new kind of manufacturing. Stephen Hoge explains Moderna’s approach to creating individualized treatments.

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